Depression care

Major Depressive Disorder Treatment in South Dakota, North Dakota & Iowa

Depression can make everything feel heavier and harder than it should. Our psychiatric team treats major depression with compassionate, evidence-based care, in person at six clinics or by secure telehealth.

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Board-certified psychiatric care Serving SD, ND & Iowa New patients welcome, no referral needed In-person & telehealth

Understanding depression

You can feel like yourself again

Major depression is a medical condition, not a personal failing. It is a lasting low mood and loss of interest that can affect sleep, appetite, energy, focus, and your sense of hope. It can happen to anyone, and it is treatable.

At MWI Health, care starts with a thorough evaluation, then a plan built around you. That plan may include therapy, medication management, or both, and it changes as you respond. For depression that has not improved with medication, we also offer advanced options.

Our providers serve South Dakota, North Dakota, and Iowa, so you can start close to home or by telehealth. No referral is required, and most people are seen without a long wait.

Signs & symptoms

What major depression can look like

If several of these last most of the day, nearly every day, for two weeks or more, it is worth talking with a provider.

Persistent sad or empty moodLoss of interest in activitiesFatigue or low energyChanges in sleepChanges in appetiteDifficulty concentratingFeelings of worthlessness or guiltSlowed thinking or movementThoughts of death or self-harm

Our approach

How we treat major depression at MWI Health

Psychiatry and therapy under one roof, coordinated by a team that communicates about your care.

1. Comprehensive evaluationWe take time to understand your symptoms and history so we can build the right plan, not a template.
2. Evidence-based therapyTalk therapy with licensed clinicians helps you process what you are going through and rebuild momentum.
3. Medication managementWhen medication can help, our psychiatric providers manage it carefully and adjust as you respond.
4. Advanced options and coordinated careIf depression has not improved with medication, we can discuss advanced options, and your team coordinates your care throughout.

Where to find care

Depression treatment across our clinics

Care for major depression is available at all six MWI Health locations, plus secure telehealth for patients in South Dakota, North Dakota, and Iowa.

South Dakota

Sioux Falls

4308 S Arway Drive
Sioux Falls, SD 57106
Mon–Fri, 8:00am–5:00pm
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South Dakota

Downtown Sioux Falls

317 North Main Avenue, Suite 100
Sioux Falls, SD 57104
Mon–Fri, 8:00am–5:00pm
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South Dakota

Rapid City

2620 Jackson Blvd, Suite G
Rapid City, SD 57702
Mon–Fri, 8:00am–5:00pm
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South Dakota

Yankton

311 Cedar St
Yankton, SD 57078
Mon–Fri, 8:00am–5:00pm
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Iowa

West Des Moines

3737 Woodland Avenue, Suite 410
West Des Moines, IA 50266
Mon–Thu, 8:00am–7:00pm
Fri, 8:00am–5:00pm
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North Dakota

Fargo

1120 28th Avenue N, Suite A
Fargo, ND 58102
Mon–Thu, 8:00am–6:00pm
Fri, 8:00am–12:00pm
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Why MWI Health

A local team built around you

Board-certified psychiatry

Led by a board-certified psychiatrist and Chief Medical Officer, with an experienced provider team.

Prompt availability

New patients welcome with no referral needed, so you are not waiting months to be seen.

Care in one place

Therapy and psychiatric care coordinated by one team that talks to each other about your plan.

In-person or telehealth

See us at one of our clinics or from home by secure telehealth across SD, ND, and IA.

Coverage

Insurance accepted

We accept most major plans and verify your benefits before your first visit.

AetnaBlue Cross Blue ShieldCignaUnitedHealthcareHumanaMedicareand more, verified before your visit

Good to know

Depression questions, answered

No referral is needed. You can request an appointment directly and we will help you get scheduled, often without a long wait.

Care usually begins with an evaluation, then a plan that may combine therapy, medication management, or both, adjusted over time based on how you respond.

Yes. Major depression is very treatable. Many people feel significantly better with therapy, medication, or a combination, and we have advanced options when standard treatment has not worked.

If low mood or loss of interest has lasted two weeks or more and is affecting your daily life, it is worth reaching out. If you are having thoughts of harming yourself, please use the crisis resources below right away.

Yes. We offer secure video visits for patients located in South Dakota, North Dakota, and Iowa.

Many new patients are seen without a long wait. Request an appointment and we will help you get scheduled at the location or telehealth option that works best for you.

We accept most major insurance plans and verify your benefits before your first visit.

Clay J. Pavlis, MD, Chief Medical Officer of MWI Health

Medically reviewed

Reviewed by Clay J. Pavlis, MD

Board-certified psychiatrist and Chief Medical Officer of MWI Health.

Meet Dr. Pavlis Last reviewed August 2026

If you need help now

Support is available right away

MWI Health provides scheduled outpatient care and is not an emergency service. If you or someone you love is in crisis, reach out to one of these free, confidential resources.

  • 988 Suicide & Crisis LifelineCall or text 988, any time, day or night.
  • Crisis Text LineText HOME to 741741.
  • EmergencyIf there is immediate danger, call 911.

Depression is treatable, and help is close

Our team is accepting new patients across South Dakota, North Dakota, and Iowa, in person and by telehealth. No referral needed.

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