Depression care

Depression Treatment in South Dakota, North Dakota & Iowa

Depression comes in more than one form, and all of them are treatable. Whatever yours looks like, our psychiatric team offers effective, evidence-based depression treatment, in person at six clinics or by secure telehealth across our region.

Board-certified psychiatric care Serving SD, ND & Iowa New patients welcome, no referral needed In-person & telehealth

Understanding depression

Effective care for every kind of depression

Depression is more than a low mood. It is a lasting loss of interest and energy that can affect sleep, focus, appetite, and your sense of hope. It is one of the most common mental health conditions, and it is very treatable.

Depression is not one thing. It includes major depression, the depressive lows of bipolar disorder, and depression that has not responded to medication. At MWI Health, we treat the full range with a plan built around you, whether that is therapy, medication management, or advanced options.

Our providers serve South Dakota, North Dakota, and Iowa, so you can start close to home or by telehealth. No referral is required, and most people are seen without a long wait.

Signs & symptoms

What depression can look like

If several of these last most of the day, nearly every day, for two weeks or more, it is worth talking with a provider.

Persistent sad or empty moodLoss of interest in activitiesFatigue or low energyChanges in sleepChanges in appetiteDifficulty concentratingFeelings of worthlessness or guiltSlowed thinking or movementThoughts of death or self-harm

Our approach

How we treat depression at MWI Health

Psychiatry and therapy under one roof, coordinated by a team that communicates about your care.

1. Comprehensive evaluationWe take time to understand your symptoms and history so we can build the right plan, not a template.
2. Evidence-based therapyTalk therapy with licensed clinicians helps you process what you are going through and rebuild momentum.
3. Medication managementWhen medication can help, our psychiatric providers manage it carefully and adjust as you respond.
4. Advanced options and coordinated careIf depression has not improved with medication, we can discuss advanced options like Spravato and TMS, and your team coordinates your care throughout.

Where to find care

Depression treatment across our clinics

Depression care is available at all six MWI Health locations, plus secure telehealth for patients in South Dakota, North Dakota, and Iowa.

South Dakota

Sioux Falls

4308 S Arway Drive
Sioux Falls, SD 57106
Mon–Fri, 8:00am–5:00pm
South Dakota

Downtown Sioux Falls

317 North Main Avenue, Suite 100
Sioux Falls, SD 57104
Mon–Fri, 8:00am–5:00pm
South Dakota

Rapid City

2620 Jackson Blvd, Suite G
Rapid City, SD 57702
Mon–Fri, 8:00am–5:00pm
South Dakota

Yankton

311 Cedar St
Yankton, SD 57078
Mon–Fri, 8:00am–5:00pm
Iowa

West Des Moines

3737 Woodland Avenue, Suite 410
West Des Moines, IA 50266
Mon–Thu, 8:00am–7:00pm
Fri, 8:00am–5:00pm
North Dakota

Fargo

1120 28th Avenue N, Suite A
Fargo, ND 58102
Mon–Thu, 8:00am–6:00pm
Fri, 8:00am–12:00pm

Why MWI Health

A local team built around you

Board-certified psychiatry

Led by a board-certified psychiatrist and Chief Medical Officer, with an experienced provider team.

Prompt availability

New patients welcome with no referral needed, so you are not waiting months to be seen.

Care in one place

Therapy and psychiatric care coordinated by one team that talks to each other about your plan.

In-person or telehealth

See us at one of our clinics or from home by secure telehealth across SD, ND, and IA.

Coverage

Insurance accepted

We accept most major plans and verify your benefits before your first visit.

AetnaBlue Cross Blue ShieldCignaUnitedHealthcareHumanaMedicareand more, verified before your visit

Good to know

Depression treatment questions, answered

No referral is needed. You can request an appointment directly and we will help you get scheduled, often without a long wait.

Care usually begins with an evaluation, then a plan that may combine therapy, medication management, or both, adjusted over time based on how you respond.

Yes. Depression is one of the most treatable mental health conditions. Most people feel significantly better with therapy, medication, or a combination.

We treat the full range, including major depressive disorder, bipolar depression, and treatment-resistant depression, as well as depression that occurs alongside anxiety. Each has dedicated, focused care.

You still have options. For treatment-resistant depression, we offer advanced treatments such as Spravato and TMS at our Sioux Falls clinic.

Yes. We offer secure video visits for patients located in South Dakota, North Dakota, and Iowa.

Many new patients are seen without a long wait. Request an appointment and we will help you get scheduled at the location or telehealth option that works best for you.

We accept most major insurance plans and verify your benefits before your first visit.

Clay J. Pavlis, MD, Chief Medical Officer of MWI Health

Medically reviewed

Reviewed by Clay J. Pavlis, MD

Board-certified psychiatrist and Chief Medical Officer of MWI Health.

Meet Dr. Pavlis Last reviewed August 2026

In a crisis

Get help right now

MWI Health is an outpatient clinic and cannot respond to emergencies. If you or someone you know is in danger or thinking about suicide, use these free, confidential resources, available 24/7.

  • Call 911Life-threatening emergency, or someone at immediate risk of harm.
  • Call or text 988Suicide & Crisis Lifeline, 24/7. Chat at 988lifeline.org/chat. In South Dakota, answered locally by the Helpline Center.
  • Dial 988, then press 1Veterans Crisis Line, or text 838255.
  • Dial 2-1-1Helpline Center, everyday support and resources. Call 211 or text your ZIP code to 898211.

Depression is treatable, and help is close

Our team is accepting new patients across South Dakota, North Dakota, and Iowa, in person and by telehealth. No referral needed.

Depression TreatmentMWI Health
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